Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

BACKGROUND The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. METHODS Epigenetically controlled lncRNAs in human umbilical vein endothelial cells were searched by exon-array analysis after knockdown of the histone ...

Long Noncoding RNA-GAS5

Long Noncoding RNA Enriched −

Robert D. Bell, Xiaochun Long, Mingyan Lin, Jan H. Bergmann, Vivek Nanda, Sarah L. Long Noncoding RNA Enriched − Identification and Initial Functional Characterization of a Human Vascular Cell Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2014 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 727...

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.

RATIONALE The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long noncoding RNAs in the vasculature are largely unknown. OBJECTIVE Here, we characterized the expression of long noncoding RNAs in human endothelial cells and elucidat...

A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells

Despite the increasing importance of long noncoding RNA in physiology and disease, their role in endothelial biology remains poorly understood. Growing evidence has highlighted them to be essential regulators of human embryonic stem cell differentiation. SENCR, a vascular-enriched long noncoding RNA, overlaps the Friend Leukemia Integration virus 1 (FLI1) gene, a regulator of endothelial develo...